Senior Scientist Positions in Cancer Immunology
Kuopio Center for Gene and Cell Therapy (KCT) is a modern research institute located in Kuopio, Finland. Our mission is to conduct high-level research on basic and translational fields of gene- and cell therapy. The center’s niche is in the interface between academic, basic research and the commercial biotechnology industry. KCT provides an exciting environment for applied research and discovery, developing therapeutic products through Phase I clinical trials and utilizing some of the most advanced analytical and mechanistic proof-of-principle approaches in the sector. Opportunities for two highly motivated Senior Scientists have now opened at the KCT Immunotherapy Program to work in projects that revolve around cancer and immune cell genetic engineering. Both projects are already active in KCT and involve clinicians, academic teams and international collaborators.
Project 1.In this project, the successful candidate will be developing T and NK based cell therapy products for ovarian and brain cancers. Lentivirus technology and CRIPR-Cas will be utilized in genetic engineering of the cells for cancer targeting and improved performance in solid cancer treatments. The candidate will closely work together with KCT team developing clinical grade cell therapy product processes. The KCT research team has already established in vitro and in vivo methods to further characterize and functionally test the developed products.
Project 2.In this project, the successful candidate will participate in establishing 3-D cultures and characterization of ovarian and brain tumors. Cell culture, immunological and molecular methods are extensively utilized. The candidate will also participate in single-cell sequencing and proteomics characterizations involving collaborative laboratories specialist in these techniques. The candidate will work together with KCT research team with extensive knowledge in cell biology, immunology and bioinformatics.
The successful candidates will be responsible for designing, implementing and overseeing their respective projects. These duties will involve practical laboratory technologies and therefore strong wet lab background is essential. This person will work closely together with internal project teams and external collaborators and therefore must have excellent communication skills in English.
- The successful applicant should hold or be about to obtain a PhD in a relevant field, such as cell biology, immunology, immuno-oncology or cancer biology.
Skills and experience in the following areas are desirable:
- Project management
- Strong overall wet lab experience
- Cell biology methods, such as primary cell isolation, 3D organoid culture, functional assays
- Multicolor flow cytometry – panel design and data analysis
- Gene editing technologies and advanced molecular methods
- Setting up and developing functional assays and analytical methods
- Furthermore, extensive understanding of such or related concepts as the human immune system activation and regulation or cancer immunosurveillance and cancer therapy is considered beneficial
- Excellent teamwork and communication skills in English are essential
- Designing, implementing and overseeing the designated research project
- Both job opportunities are Senior Scientist positions
The positions are initially filled for three years. International candidates are strongly encouraged to apply. KCT’s HR team are available to help with issues related to relocation.
Electronic application with cover letter including preference of the project, curriculum vitae, contact details of two referees and salary expectations should be sent by 22ndSeptember 2019. (Please note, this job announcement is circulated via the Finnish Society for Immunology network ahead of the formal application process. The electronic application form will be open at https://www.kct.fi/join-uslater in August 2019; prior to that applications and informal enquiries can be sent to the address below.)
Further information: anssi . kailaanmaki [at] kct . fi
Dr. Anssi Kailaanmäki, Head of Immunotherapy
University of Pennsylvania, Philadelphia, USA Children’s Hospital of Philadelphia
We seek a highly-motivated and self-sufficient post doc to join our human immunology laboratory. Candidates should possess or soon possess PhD degrees in immunology, cell/molecular biology, genetics or related fields. The available position is to study epigenetic regulation of healthy and diseased germinal center reactions using genome wide technologies including RNA-seq, CHiP-seq and ATAC-seq. The post doc filling this position will also have opportunities to work on/lead
disease discovery projects. Competitive candidates need to possess experience in flow cytometry, cell sorting and molecular biology. Experience in genome editing and analysis of large genomic data sets are also favored.
The offered position is funded for approximately five years. For productive post-docs there will be opportunities to present scientific data at local, national and international meeting. Salary is competitive and will depend upon qualifications and previous training. A summer/autumn 2019 start date is preferred.
The research activity will take place in a highly academic environment. The lab is located on the 12th floor of the Abramson Research Center, a part of Children’s Hospital Philadelphia (CHOP) Research Institute. The institute is one of the largest and prestigious pediatric research programs in the USA with 425 full time investigators working in 700,000 square feet across three dedicated research buildings. CHOP is situated within the the University of Pennsylvania Campus and is home to the Pediatrics Faculty of the University of Pennsylvania Perelman School of Medicine, an Ivy League medical school. This rich, intellectual environment is ideal for the conduct of interdisciplinary and innovative research.
Philadelphia, the 6th most-populous U.S. city, provides a dynamic cultural environment and numerous forms of entertainment. Philadelphia is easy to access through its large international airport. New York City is only 90 minutes by train.
More information about the Romberg Lab can be viewed at the following URL (romberglab.org)
Interested candidates should email the following to firstname.lastname@example.org:
- A cover letter with a short description of achievements and a description how this opportunity fits within their anticipated career trajectory
- A CV with a complete list of publications
- The contact info for two references
Are you interested in adaptive immunology and immunodeficiencies?
Dr. Eliisa Kekäläinen (Adj. professor, MD PhD) and her small research group are studying the adaptive immune system in different situations where some small or a larger part of the immune system is missing or working poorly (inborn or acquired immunodeficiencies). Dr. Kekäläinen’s group is a member of the Translational Immunology Research Program at University of Helsinki. We have a project that is focused on the ultimate treatment-related immunodeficiency, i.e. stem-cell transplantation, and we study how the adaptive immune system recuperates from it. We also study basic immunological mechanisms using rare congenital immunodeficiencies as models. We study only human immunology and aim to use cutting-edge technology to answer these complex research questions. For example, we are currently developing single-cell omics methods for simultaneous transcriptome and immunophenotype analysis.
Our group is small and just starting up, so every member in our group will be a key player. A perfect candidate would be proactive, independent, curious, and ambitious. Good English oral and writing skills are essential. Experience with flow-cytometry and/or transcriptomics are appreciated.
If you are interested, we have both master’s degree and PhD projects available. Please contact Dr. Eliisa Kekäläinen directly: email@example.com