{"id":717,"date":"2020-12-06T16:42:46","date_gmt":"2020-12-06T16:42:46","guid":{"rendered":"http:\/\/immunologiayhdistys.fi\/?page_id=717"},"modified":"2026-01-27T06:41:50","modified_gmt":"2026-01-27T06:41:50","slug":"tapahtumat","status":"publish","type":"page","link":"https:\/\/immunologiayhdistys.fi\/en\/tapahtumat\/","title":{"rendered":"Events"},"content":{"rendered":"\t\t
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Immunology seminar series<\/strong><\/h3>\n
\n

Immunology Seminar Series<\/strong><\/p>\n

Immunology Seminar Series<\/p>\n

February 3rd at 14-15 (Finland time)<\/p>\n

Virtual event<\/p>\n

Taija M\u00e4kinen, University of Helsinki: Lymphatic vasculature as a
guardian of tissue homeostasis and inflammation<\/p>\n

Zoom link available from organizers<\/p>\n

Register for the Immunology Seminar Series email list to get calendar
invitations to the online seminars:
https:\/\/link.webropolsurveys.com\/S\/D29C32AA6E8A2F7A<\/a> <\/p>\n

Host: Professor Riitta Lahesmaa ( rilahes[at]utu.fi<\/a> )<\/p>\n

Immunology seminar series is jointly organised by the Finnish Society
for Immunology, InFLAMES Flagship and Turku Bioscience. For further
information contact Anne Lahdenper\u00e4  ( ankahy[at]utu.fi<\/a> ) or Riitta
Lahesmaa ( rilahes[at]utu.fi<\/a> ), University of Turku.<\/p>\n

Taija M\u00e4kinen obtained her PhD from the University of Helsinki and
completed postdoctoral training at the Max Planck Institute of
Neurobiology in Martinsried, Germany. She previously served as a group
leader at the Cancer Research UK London Research Institute (now the
Francis Crick Institute) and later as Professor at Uppsala University.
In 2024, she returned to Finland and currently serves as Director of the
Wihuri Research Institute and Professor at the Faculty of Medicine,
University of Helsinki. Her research focuses on the mechanisms
regulating the lymphatic vascular system and its roles in health and
disease.<\/p>\n

Recent selected publications:<\/p>\n

Kraft M, Schoofs H, Petkova M, Andrade J, Grosso AR, Benedito R, De Roo
AK, Boon LM, Vikkula M, Kapp FG, H\u00e4gerling R, Potente M, M\u00e4kinen T.
Angiopoietin-TIE2 feedforward circuit promotes PIK3CA-driven venous
malformations. Nat Cardiovasc Res. 2025 Jul;4(7):801-820. doi:
10.1038\/s44161-025-00655-9.<\/p>\n

Schoofs H, Daubel N, Schnabellehner S, Gr\u00f6nloh MLB, Palacios Mart\u00ednez
S, Halme A, Marks AM, Jeansson M, Barcos S, Brakebusch C, Benedito R,
Engelhardt B, Vestweber D, Gaengel K, Linsenmeier F, Sch\u00fcrmann S,
Saharinen P, van Buul JD, Friedrich O, Smith RS, Majda M, M\u00e4kinen T.
Dynamic cytoskeletal regulation of cell shape supports resilience of
lymphatic endothelium. Nature. 2025 May;641(8062):465-475. doi:
10.1038\/s41586-025-08724-6.<\/p>\n

Petkova M, Kraft M, Stritt S, Martinez-Corral I, Orts\u00e4ter H,
Vanlandewijck M, Jakic B, Baselga E, Castillo SD, Graupera M, Betsholtz
C, M\u00e4kinen T. Immune-interacting lymphatic endothelial subtype at
capillary terminals drives lymphatic malformation. J Exp Med. 2023 Apr
3;220(4):e20220741. doi: 10.1084\/jem.20220741.<\/p>\n

Hern\u00e1ndez V\u00e1squez MN, Ulvmar MH, Gonz\u00e1lez-Loyola A, Kritikos I, Sun
Y, He L, Halin C, Petrova TV, M\u00e4kinen T. Transcription factor FOXP2 is
a flow-induced regulator of collecting lymphatic vessels. EMBO J. 2021
Jun 15;40(12):e107192. doi: 10.15252\/embj.2020107192.<\/p>\n

Martinez-Corral I, Zhang Y, Petkova M, Orts\u00e4ter H, Sj\u00f6berg S, Castillo
SD, Brouillard P, Libbrecht L, Saur D, Graupera M, Alitalo K, Boon L,
Vikkula M, M\u00e4kinen T. Blockade of VEGF-C signaling inhibits lymphatic
malformations driven by oncogenic PIK3CA mutation. Nat Commun. 2020 Jun
8;11(1):2869. doi: 10.1038\/s41467-020-16496-y.<\/p>\n

Links:
——
[1] 
https:\/\/bioscience.fi\/wp-content\/uploads\/2025\/12\/ISS-A4Makinen-03022026.jpg?x24946<\/a>
[2] https:\/\/utu.zoom.us\/j\/69783530648<\/a>
[3] https:\/\/link.webropolsurveys.com\/S\/D29C32AA6E8A2F7A<\/a><\/p>\n

\n

December 9th at 14-15 (Finland time)<\/p>\n

Virtual event<\/p>\n

Flyer<\/a><\/p>\n

P\u00e4rt Peterson,<\/strong> University of Tartu, Estonia: Autoantibodies to type 1 interferons in Aire-deficient hosts<\/p>\n

Link to join the zoom meeting: https:\/\/utu.zoom.us\/j\/64207182900<\/a><\/p>\n

Register for the Immunology Seminar Series email list to get calendar invitation to the online seminar: https:\/\/link.webropolsurveys.com\/S\/D29C32AA6E8A2F7A<\/a><\/p>\n

Host: Professor Riitta Lahesmaa ( rilahes[\u00e4t]utu.fi )<\/p>\n

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenper\u00e4  ( ankahy[\u00e4t]utu.fi ) or Riitta Lahesmaa ( rilahes[\u00e4t]utu.fi ), University of Turku.<\/p>\n

P\u00e4rt Peterson<\/strong> is a Professor of Molecular Immunology and Head of the Institute of Biomedicine and Translational Medicine at the University of Tartu, Estonia. He defended his PhD in molecular immunology in 1996 at the University of Tampere, Finland and he has been a Fellow of the Finnish Academy, The Wellcome Trust International Senior Fellow, and the Research Professor of the Academy of Estonia. Since 2008, he has been a Professor of Molecular Immunology at the University of Tartu, Estonia. Year 2023 he was elected member of the Estonian Academy of Sciences.
P\u00e4rt Peterson leads Molecular Pathology Research Group at the University of Tartu. His main focus is to understand the transcriptional and epigenetic regulation in cells involved in immune response and tolerance. His research interest has focused on the Central immune tolerance and the function of the Autoimmune Regulator (AIRE) gene in the thymus. His second research direction is Immunopathology of APECED (or APS1) disease, in which patients develop multiple endocrine autoimmune disorders and chronic mucocutaneous candidiasis. He co-discovered and made initial characterization of the DNA methyltransferase 3-like (DNMT3L) gene, a regulator of DNA methylation and epigenetic imprinting. P\u00e4rt Peterson group studies the role of autoantibodies to type 1 interferon and other cytokines, and their presence among autoimmune patients and in aged individuals and also age-related changes in old individuals to understand the molecular and cellular drivers of these processes. They combine molecular and cellular approaches with immunology tools and use genome-wide transcriptomic and epigenetic analyses, also single-cell approaches on immune cells.<\/p>\n

<\/p>\n

Selected publications:<\/p>\n

Stoljar A, Zarodniuk M, Bichele R, Armulik EH, Haljasorg U, Humeau R, Besnard M, Haljasm\u00e4gi L, Tserel L, Peltser M, Salumets A, Kek\u00e4l\u00e4inen E, Kisand K, Guillonneau C, Laan M, Peterson P. Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFN\u03b1. J Exp Med. 2025 Jul 7;222(7):e20241403. doi: 10.1084\/jem.20241403.<\/p>\n

Giraud M, Peterson P. The Autoimmune Regulator (AIRE) Gene, The Master Activator of Self-Antigen Expression in the Thymus. Adv Exp Med Biol. 2025;1471:199-221. doi: 10.1007\/978-3-031-77921-3_7..<\/p>\n

Laan M, Salumets A, Klein A, Reintamm K, Bichele R, Peterson H, Peterson P. Post-Aire Medullary Thymic Epithelial Cells and Hassall’s Corpuscles as Inducers of Tonic Pro-Inflammatory Microenvironment. Front Immunol. 2021 Apr 2;12:635569. doi: 10.3389\/fimmu.2021.635569.<\/p>\n

Ossart J, Moreau A, Autrusseau E, M\u00e9noret S, Martin JC, Besnard M, Ouisse LH, Tesson L, Flippe L, Kisand K, Peterson P, Hubert FX, Anegon I, Josien R, Guillonneau C. Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease. J Immunol. 2018 Aug 1;201(3):874-887. doi: 10.4049\/jimmunol.1701318. Epub 2018 Jun 29.<\/p>\n

\n

November 4th at 14-15 (Finland time)<\/p>\n

Virtual event<\/p>\n

Jonna Alanko, <\/strong>Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University: Dendritic cell navigation and self-generated chemokine gradients<\/p>\n

Link to join the zoom meeting: https:\/\/utu.zoom.us\/j\/63682411952<\/a><\/p>\n

<\/p>\n

Register for the Immunology Seminar Series email list to get calendar invitation to the online seminar: https:\/\/link.webropolsurveys.com\/S\/D29C32AA6E8A2F7A<\/a><\/p>\n

Host: Professor Riitta Lahesmaa ( rilahes[\u00e4t]utu.fi )<\/p>\n

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenper\u00e4  ( ankahy[\u00e4t]utu.fi ) or Riitta Lahesmaa ( rilahes[\u00e4t]utu.fi ), University of Turku.<\/p>\n

***<\/p>\n

PhD Jonna Alanko<\/strong> is a Principal Investigator at the Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, and the winner of the Scandinavian Society for Immunology (SSI) Young Investigator Award 2025 from Finland. Jonna completed her PhD in 2016 in Prof. Johanna Ivaska\u2019s group at the University of Turku, after which she conducted extensive postdoctoral research abroad in Prof. Michael Sixt\u2019s group at the Institute of Science and Technology Austria (ISTA). After returning to Finland, Jonna continued her career as an InFLAMES Postdoctoral Fellow in Prof. Marko Salmi\u2019s group until securing funding for her own research group (InstruFellow and Academy Research Fellow).<\/p>\n

Jonna and her Immune Cell Navigation<\/em> group investigate how immune cells\u2014particularly dendritic cells\u2014migrate and navigate in response to different molecular cues, using various live-cell migration setups (https:\/\/bioscience.fi\/immune-cell-navigation\/<\/a>). Jonna\u2019s previous work revealed dendritic cell\u2013generated CCL19 gradients as a previously unknown guidance mechanism, and her group is now continuing this research to open new avenues for understanding immune responses. Their research aims to uncover the detailed mechanisms of leukocyte navigation, with the ultimate goal of therapeutically manipulating these mechanisms to guide cells to desired locations, such as toward tumors or away from autoimmune sites.<\/p>\n

Selected publications:<\/strong><\/p>\n

Alanko, J., U\u00e7ar, M.C., Canigova, N., Stopp, J., Schwarz, J., Merrin, J., Hannezo, E., and Sixt, M. (2023) CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration. Sci Immunol 8<\/em>, eadc9584, DOI:10.1126\/sciimmunol.adc9584<\/a><\/p>\n

U\u00e7ar, M.C., Alsberga, Z., Alanko, J., Sixt, M. & Hannezo, E. (2025) Self-generated chemotaxis of mixed cell populations, PNAS 122 (34) e2504064122, DOI: 10.1073\/pnas.2504064122<\/a><\/p>\n

\n

June 3rd at 14-15 (Finland time)<\/p>\n

Virtual event<\/p>\n

Sini Laakso<\/strong>, University of Helsinki: Exploring germinal center reaction and role of Epstein Barr virus by accessing deep cervical lymph nodes of patients with multiple sclerosis<\/p>\n

Link to the online seminar: https:\/\/utu.zoom.us\/j\/62550568313<\/a><\/p>\n

Register for the Immunology Seminar Series email list to get calendar invitation to the online seminar: https:\/\/link.webropolsurveys.com\/S\/D29C32AA6E8A2F7A<\/a><\/p>\n

Host: Professor Riitta Lahesmaa ( rilahes[at]utu.fi<\/a> )<\/p>\n

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenper\u00e4  ( ankahy[at]utu.fi<\/a> ) or Riitta Lahesmaa ( rilahes[at]utu.fi<\/a> ), University of Turku.<\/p>\n

<\/p>\n

Sini Laakso<\/strong>, MD PhD, docent, is a group leader in University of Helsinki, Translational Immunology Research Program and a neurologist in Helsinki University Hospital, Brain center. Her PhD in the group of Petteri Arstila, University of Helsinki, investigated T cell homeostasis in patients with Autoimmune Polyendocrinopathy -Candidiasis- Ectodermal Dystrophy and was completed in 2012, three years after the MD degree. She then went on to specialize in neurology, degree achieved in 2020 and participated in post doc work in the group of professor Pentti Tienari. She was a Research Council of Finland Clinical researcher 2020-2024, starting her own group to investigate cervical lymph nodes in MS. Her group also has a wider interest in autoimmune neurology. She started as a Sigrid Juselius established clinical researcher in Jan 2025.<\/p>\n

Link to publication list<\/a><\/p>\n

\n

May 6th, 2025, at 14-15 (Finland time)<\/p>\n

Virtual event<\/p>\n

Flyer<\/a><\/p>\n

Kirsi Rautajoki, <\/strong>Faculty of Medicine and Health Technology, Tampere University: Mapping the immune landscape of diffuse astrocytoma brain tumors<\/p>\n

Host: Professor Riitta Lahesmaa ( rilahes[at[utu.fi )<\/p>\n

Link to the online seminar: https:\/\/utu.zoom.us\/j\/67064439108<\/a><\/p>\n

If you do not yet receive calendar invitations to the Immunology Seminars subscribe to Immunology Seminar Series email list: https:\/\/link.webropolsurveys.com\/S\/D29C32AA6E8A2F7A<\/a><\/p>\n

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenper\u00e4  ( ankahy[at]utu.fi ) or Riitta Lahesmaa ( rilahes[at]utu.fi ), University of Turku.<\/p>\n

*****<\/p>\n

Adjunct Professor Kirsi Rautajoki<\/strong> leads the Cancer Regulation and Immunology research group, which investigates how immunosuppression is established and sustained in the brain tumor microenvironment. The group also explores how altered epigenetic and gene regulation drive malignancy and cell plasticity by hijacking normal stem cell regulatory mechanisms. Additionally, they develop novel DNA methylation-based methods for brain tumor diagnostics and treatment.<\/p>\n

Their research focuses on brain tumors, particularly glioblastoma, diffuse gliomas, and atypical teratoid rhabdoid tumors (AT\/RTs). The team comprises both computational and experimental researchers with expertise in epigenetics, gene expression, single-cell, and spatial analysis methods. They collaborate closely with clinical experts and primarily utilize patient samples and in-house patient-derived cell and tissue models.<\/p>\n

Adj. Prof. Kirsi Rautajoki has a background in immunology, specializing in T-cell signaling and differentiation. Following her Ph.D., she transitioned into cancer genomics and brain tumor research. Currently, she is a university lecturer and the principal investigator (PI) of the Cancer Regulation and Immunology research group. She is also the co-founder and chair of Finnish Brain Tumor Research Association (FiBTRA), an initiative fostering collaboration between researchers and clinical experts in central nervous system tumor research. Additionally, she is an active member of Prostate Cancer Research Center (PCRC), FICAN-MID Tays cancer centre, and Tampere Brain & Mind.<\/p>\n

<\/p>\n

Selected publications:<\/p>\n

Hermelo, I., Virtanen, T., Salonen, I., N\u00e4tkin, R., Keitaanniemi, S., Tiihonen, A., Lehtipuro, S., Kummola, L., Raulamo, E., Nordfors, K., Haapasalo, H., Rauhala, M., Kesseli, J., Nykter, M., Haapasalo, J., Rautajoki, K.J. (2025) Unsupervised clustering reveals noncanonical myeloid cell subsets in the brain tumor microenvironment. Cancer Immunol. Immunother. 74:63.<\/p>\n

Governa, V., de Oliveira, K.G., B\u00e5ng-Rudenstam, A., Offer, S., Cerezo-Maga\u00f1a, M., Li, J., Beyer, S., Johansson, M.C., M\u00e5nsson, A.-S., Edvardsson, C., Durmo, F., Gustafsson, E., Boukredine, A., Jeannot, P., Schmidt, K., Gezelius, E., Menard, J.A., Garza, R., Jakobsson, J., de Neergaard, T., Sundgren, P.C., Tiihonen, A.M., Haapasalo, H., Rautajoki, K.J., Nordenfelt, P., Darabi, A., Forsberg-Nilsson, K., Pietras, A., Talbot, H., Bengzon, J., Belting, M. (2024) Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted. Sci. Transl. Med. 16:eadk1168.<\/p>\n

Rautajoki, K.J., Jaatinen, S., Hartewig, A., Tiihonen, A.M., Annala, M., Salonen, I., Valkonen, M., Simola, V., Vuorinen, E.M., Kivinen, A., Rauhala, M.J., Nurminen, R., Maass, K.K., Lahtela, S-L., Jukkola, A., Yli-Harja, O., Hel\u00e9n, P., Pajtler, K.W., Ruusuvuori, P., Haapasalo, J., Zhang, W., Haapasalo, H., Nykter, M. (2023) Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting. Acta Neuropathol. Commun. 11:176.<\/p>\n

<\/p>\n<\/div>\n

 <\/div>\n
\n
\n

June 4th, 2024 online at 14 \u2013 15 (Finland time)<\/h3>\n

Virtual event<\/p>\n

Flyer<\/a><\/p>\n

Mihai Netea<\/strong>, Radboud University Medical Center, Nijmegen, the Netherlands: \u201cTrained immunity \u2013 a memory for innate host defense\u201d<\/p>\n

Please register latest June 3rd at https:\/\/link.webropolsurveys.com\/S\/2FB4958BE8EB467A<\/a><\/p>\n

Host: Riitta Lahesmaa ( rilahes[at]utu.fi<\/a> )<\/p>\n

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenper\u00e4  ( ankahy[at]utu.fi<\/a> ) or Riitta Lahesmaa ( rilahes[at]utu.fi<\/a> ), University of Turku.<\/p>\n

***<\/p>\n

Mihai Netea<\/strong> was born and studied medicine in Cluj-Napoca, Romania. He completed his PhD at the Radboud University Nijmegen, The Netherlands, on studies investigating the cytokine network in sepsis. After working as a post-doc at the University of Colorado, he returned to Nijmegen where he finished his clinical training as an infectious diseases specialist, and where he currently heads the division of Experimental Medicine, Department of Internal Medicine, Nijmegen University Nijmegen Medical Center. He is mainly interested in understanding the memory traits of innate immunity (trained immunity)<\/em>, the factors influencing variability of human immune responses, and the immune dysregulation during bacterial and fungal infections. He is the recipient of the Spinoza Prize 2016 and an ERC Advanced grant in 2019, and since 2016 he is a member of the Netherlands Royal Academy of Sciences (KNAW).<\/p>\n

Selected publications:<\/p>\n

    \n
  1. Giamarellos-Bourboulis EJ, Tsilika M, Moorlag S, \u2026 , Papadopoulos A, Netea MG. Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly.<\/a> 2020 Oct 15;183(2):315-323.e9<\/li>\n<\/ol>\n
      \n
    1. Katzmarski N, Dom\u00ednguez-Andr\u00e9s J, Cirovic B, \u2026 Schultze JL, Roger T, Giamarellos-Bourboulis EJ, Schlitzer A, Netea MG. Transmission of trained immunity and heterologous resistance to infections across generations.<\/a> Nat Immunol. 2021 Nov;22(11):1382-1390<\/li>\n
    2. Bekkering S, Arts RJW, \u2026 , Stunnenberg H, Riksen NP, Netea MG. Metabolic Induction of Trained Immunity through the Mevalonate Pathway.<\/a> Cell. 2018; 172:135-146<\/li>\n<\/ol>\n
        \n
      1. Mitroulis I, Ruppova K, Wang B, \u2026 , Hajishengallis G, Netea MG, Chavakis T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.<\/a> 2018; 172:147-161<\/li>\n
      2. Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O\u2019Neill LA, Xavier RJ. Trained immunity: A program of innate immune memory in health and disease.<\/a> 2016 Apr 22;352(6284):aaf1098<\/li>\n<\/ol>\n<\/div>\n
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         <\/div>\n

        \"\"<\/p>\n

        May 7th, 2024, online at 14-15: Katri Lindfors<\/span><\/b><\/div>\n
        \n

        Katri Lindfors<\/span><\/b>, Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University: Phenotypic spectrum of celiac disease \u2013 a quest for underlying mechanisms<\/i><\/span><\/p>\n

        Please register latest May 6th<\/sup> at  <\/span>https:\/\/link.webropolsurveys.com\/S\/EE67FF858AC0A584<\/span><\/a><\/span><\/p>\n

        Host: Riitta Lahesmaa ( rilahes[\u00e4t]utu.fi<\/a> )<\/span><\/p>\n

        Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenper\u00e4  ( <\/span>ankahy[\u00e4t]utu.fi<\/span><\/a><\/span> ) or Riitta Lahesmaa ( <\/span>rilahes[\u00e4t]utu.fi<\/span><\/a><\/span> ), University of Turku.<\/span><\/p>\n

        ***<\/span><\/p>\n

        Katri Lindfors<\/span><\/b> is a professor of molecular biology and the vice director of Celiac Disease Research Center at Tampere University. She is a member of the organizing committee of the Tampere Celiac Disease Symposium, the scientific advisory board of the patient organization Finnish Celiac Society and International Society for the Study of Celiac Disease.<\/span><\/p>\n

        She has conducted translational celiac disease research over 20 years and published over 100 peer-reviewed articles. Her previous work has contributed to the understanding of factors involved in celiac disease pathogenesis including the potential role of enteroviruses as a triggering factor and the biological functions of celiac disease specific autoantibodies targeting a self-protein transglutaminase 2 (TG2).  Currently her group focuses on identifying factors contributing to the heterogenous clinical picture of celiac disease using dermatitis herpetiformis, the skin manifestation of celiac disease, as a model phenotype. Up to now, her results indicate that in addition to a distinct genetic predisposition, an autoimmune response against a TG3, a homologue of celiac disease autoantigen TG2 is implicated in dermatitis herpetiformis. Ongoing studies are addressing the questions whether dermatitis herpetiformis pathogenesis is initiated in the small bowel mucosa and how the disease spreads from gut to skin as a consequence of unrecognized and untreated celiac disease.<\/span><\/p>\n

        References: <\/span><\/b><\/p>\n